Abstract : A novel myokine called irisin is produced in humans after exercise. The present study aimed to determine the effect of irisin values on the levels of BMI, CBC, leptin, and lipid profiles. Between November 2021 and February 2022, 100 Iraqi women aged 18-38 were divided into two groups: those who practicing sports and those who did not. Venous blood was collected and transferred into EDTA tubes and Gel Activator tubes. The current study found a highly significant increase in irisin (p≤0.01) in women practicing sports but no significant difference (P≤0.05) in leptin in women participating in sports (using the ELISA kit). A significant decrease (P≥0.05) in BMI and an increase (P<0.05) in RBCs, MCV, HCT, RDW, Hb, MPV, and PDW in women practicing sports. But, no influence (P≥0.05) was found in MCH, PLT, and PCT in women practicing sports. In cholesterol, triglycerides, LDL, and VLDL decreased (P≥0.01) in women practicing sports, while HDL increased significantly (P≤0.01) in these women. Results of the women practicing sports show increased irisin and rbc due to the high effect of exercise on women practicing sports and an increase in oxygen supply in both blood and tissue, but a decrease in leptin, BMI, cholesterol, triglycerides, LDL, and VLDL, and an increase in HDL refer to weight loss.