Nephropathy is one of the serious diabetic comorbid complications. Propolis has been used for the treatment of various illnesses due to its complex composition of various therapeutic constituents including antioxidant compounds which might help regenerate the pancreas or facilitate tissue glucose utilization or improve insulin action. The present study aimed to demonstrate a comparative renoprotective effect provided by vitamin E or propolis in the same diabetic patient sample on standard therapy of sitagliptin plus metformin therapy. To do so serum sample has been collected before (baseline) and after the addition of vitamin E (8 weeks) or propolis (8 weeks) to the patient therapy; the serum was frozen until analysis. The consecutive application of either vitamin E or propolis was carried out with a one-week washout period in-between both courses of therapy. The results demonstrate that propolis provides intensified renoprotection rate indicated by significantly (p<0.05) reducing the level of creatinine, uric acid, and urea alongside improved microalbuminuria. The study concluded that compared to vitamin E; propolis induced a positive effect on one of the major diabetic devastating complications, nephropathy. We do advise diabetic patients to add regular propolis doses to their standard therapy.